Abstract: Laparoscopic cholecystectomy is the gold standard for the treatment of gallstones and chronic cholecystitis. A patient with gallstone was admitted to the 88th Hospital of PLA in August 2012 and received laparoscopic cholecystectomy. She had bile leakage after operation, and had to accept reoperation. Pancreaticobiliary maljunction and aberrant duct upon gallbladder bed were found postoperatively by T tube cholangiography and pancreatic amylase test in the bile, which led to a complicated treatment and a tortuous recovery. This article analyzed the treatment process for this disease and explore the proper diagnosis and treatment .